DM1 Rabbit Monoclonal Antibody [Clone ID: 14E3]

SKU TA421208

Rabbit monoclonal anti-DM1 (ADC Payload) Antibody, Clone 14E3

Product Data

• Clone Name: 14E3
• Application: ELISA
• Recommended Dilution: ELISA 1:5000-10000
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Reconstitution Method: Reconstitute with sterile, low-endotoxin water. See the COA for more details
• Concentration: Lot specific
• Purification: Purified from cell culture supernatant by affinity chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing)
• Stability: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
• Shipping: Ambient
• Background: DM1, also known as mertansine, represents a promising class of ADCs. As a microtubulin inhibitor, DM1 disrupts microtubule assembly by binding to tubulin at the rhizoxin binding site. The ingenious concept behind ADCs involves coupling DM1 to a monoclonal antibody, enabling targeted delivery to tumor cells. Notably, trastuzumab emtansine (T-DM1) has already gained approval for HER2-positive breast cancer treatment, exemplifying the potential of DM1-based ADCs in precision oncology.

Reference Data