Eribulin Rabbit Monoclonal Antibody [Clone ID: 3E2]

SKU TA421205S

Rabbit monoclonal anti-Eribulin (ADC Payload) Antibody, Clone 3E2

Product Data

• Clone Name: 3E2
• Application: ELISA
• Recommended Dilution: ELISA 1:5000-10000
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Reconstitution Method: Reconstitute with sterile, low-endotoxin water. See the COA for more details
• Concentration: Lot specific
• Purification: Purified from cell culture supernatant by affinity chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing)
• Stability: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
• Shipping: Ambient
• Background: Eribulin, a fully synthetic macrocyclic ketone analogue derived from the marine sponge Halichondria okadai, shows promise as an ADC payload. Its anti-tumor activity involves inhibiting microtubule elongation and mitotic spindle formation, leading to apoptosis. Eribulin-based ADCs offer advantages such as well-understood toxicity profiles and compatibility with various linker chemistries. Clinical development includes MORAb-202, an ADC targeting folate receptor alpha (FRα) in solid tumors.

Reference Data