CL2A Rabbit Monoclonal Antibody [Clone ID: 1H2]

SKU TA421199AM

Rabbit monoclonal anti-CL2A (ADC linker) Antibody, Clone 1H2, Biotinylated

Product Data

• Clone Name: 1H2
• Application: ELISA
• Recommended Dilution: ELISA 1:5000-10000
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Reconstitution Method: Reconstitute with sterile, low-endotoxin water. See the COA for more details
• Concentration: Lot specific
• Purification: Purified from cell culture supernatant by affinity chromatography
• Conjugation: Biotin
• Storage: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing)
• Stability: Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
• Shipping: Ambient
• Background: CL2A is a crucial component in antibody-drug conjugate (ADC) therapy, acting as a chemical linker that connects a potent DNA topoisomerase I inhibitor, SN-38, to an antibody. Representing Cysteine-Linked 2-Aminoethyl, CL2A features a complex structure with a PEG8 chain, a triazole ring, a PABC-peptide, and a maleimide group. The maleimide group binds to a cysteine residue on the antibody, facilitating targeted drug delivery. Designed to release SN-38 in acidic cancer cell environments, CL2A induces DNA damage and cell death. This versatile linker is employed in ADCs targeting various antigens like Trop-2 or HER2, tailored to specific cancer types.

Reference Data