BAF53A (ACTL6A) Rabbit Polyclonal Antibody
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB: 1:500~1:1000 IHC: 1:50~1:200 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide, corresponding to amino acids 211-260 of Human BAF53. |
| Specificity | BAF53 (W237) polyclonal antibody detects endogenous levels of BAF53 protein. |
| Buffer | Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
| Concentration | 1mg/ml |
| Conjugation | Unconjugated |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | ~ 47 kDa |
| Gene Name | actin like 6A |
| Database Link | |
| Background | The SWI/SNF complex regulates gene expression via ATP-dependent chromatin remodeling. Brm (SNF2-a), Brg-1 (SNF2-b), Ini1 (integrase interactor 1, SNF5), BAF53 (ARPnβ), BAF57, BAF155 (SRG3), and BAF170 make up the functional core. BAF53 homologues from yeast to humans contain a conserved N-terminal motif, which contains residues at serine 2 and tyrosine 6, which play important roles in BAF53 activity. The BAF53 protein shuttles between the nucleus and cytoplasm. BAF53 also forms a complex with TIP49 and TIP48, which mediates c-Myc oncogenic activity. |
| Synonyms | 53 kDa BRG1-associated factor A; Actin-like protein 6A; Actin-related protein Baf53a; ACTL6A; ArpNbeta; BAF53; BAF53A; BRG1-associated factor 53A; INO80 complex subunit K; INO80K |
| Note | For research use only, not for use in diagnostic procedure. |
| Reference Data | |
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