Casr Rabbit Polyclonal Antibody

SKU TA388997

Anti-CaSR Antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 1:1000
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide from the N-terminus region of rat calcium sensing receptor, conjugated to keyhole limpet hemocyanin (KLH).
• Specificity: Specific for endogenous levels of the ~130-260 kDa CaSR protein.
• Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
• Concentration: lot specific
• Purification: Antigen Affinity Purified from Pooled Serum
• Conjugation: Unconjugated
• Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
• Stability: After date of receipt, stable for at least 1 year at -20°C.
• Shipping: Blue Ice
• Predicted Protein Size: 130/260
• Gene Name: calcium-sensing receptor
• Database Link:
  P41180
• Background: Calcium sensing receptor, CaSR, is a unique G protein-coupled receptor activated by extracellular Ca2+, Mg2+, Sr2+, Mn2+, Ba2+, Ni2+, Al2+, Gd3+, amino acids, polyamines, pH and ionic strength (Quinn, S.J. et al., 1998). CaSR is a cell surface dimer located in the caveolin-rich plasma membrane domains (Kifor, O., et al., 1998). CaSR tightly regulates extracellular calcium levels to avoid hyper/hypo-calcemia through complex interactions with PTH, calcitonin, and vitamin D by balancing their effects on the parathyroid glands, bone, kidney, and intestine (Díaz-Soto, G. et al., 2016). Additionally, CaSR has been identified in the nervous system and recent studies suggest CaSR as a direct target of reducing Aβ42 secretion that may contribute to Alzheimer’s Disease (Armato, U., et al., 2013). Recent studies have shown CaSR negatively impacts the formation and progression of neuroblastomas by calcium exposure leading NB cells overexpressing CaSR to undergo apoptosis by means of activating ERK1/2 (Casalà, C., et al., 2013).
• Synonyms: CAR; EIG8; FHH; FIH; GPRC2A; HHC; HHC1; MGC138441; NSHPT; PCAR1
• Note: Prepared from pooled rabbit serum by affinity purification on a column made with the N-terminal peptide used as antigen.

Reference Data