CD41 (ITGA2B) Rabbit Monoclonal Antibody [Clone ID: 1000000]

SKU TA385996

Recombinant Anti-GPIIb/IIIa (Clone 10E5)

Product Data

• Clone Name: 1000000
• Application: ELISA, IF, WB
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG, kappa
• Clonality: Monoclonal
• Immunogen: Human blood platelets.
• Specificity: The antibody binds to GPIIb/IIIa with an affinity (Kd) of 16.2±6 nM. The antibody completely inhibits platelet aggregation at 7.8 µg/ml.; ; The antibody binds specifically to human GPIIb/IIIa, and integrin complex of membrane glycoproteins expressed on the surface of platelets. The GPIIb/IIIa complex acts as a receptor for fibrinogen and Von Willebran factor, hemostatic glycoproteins that mediate platelet aggregation and blood coagulation. The monoclonal antibody 10E5 inhibits the binding of fibrinogen to its platelet receptor, preventing the platelet aggregation, to be used during coronary artery surgeries such as angioplasty. The antibody is also useful in the study of the disease Glanzmann's thrombasthenia, caused by defects in GPIIb/IIIa, and of immune thrombocytopenic purpura, where autoantibodies are produced against GPIIb/IIIa.
• Buffer: PBS with 0.02% Proclin 300.
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
• Stability: 3 years from dispatch.
• Shipping: Blue Ice
• Gene Name: integrin subunit alpha 2b
• Database Link:
  P08514
• Synonyms: CD41; CD41B; GP2B; GPIIb; GTA; HPA3; ITGAB
• Note: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Reference Data