TRIM23 Rabbit Monoclonal Antibody [Clone ID: R09-4K7]
| Product Data | |
| Clone Name | R09-4K7 |
|---|---|
| Application | WB |
| Recommended Dilution | WB: 1/2000-1/10000 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthetic peptide of human TRIM23 |
| Buffer | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | Calculated MW: 64 kDa; Observed MW: 64 kDa |
| Gene Name | tripartite motif containing 23 |
| Database Link | |
| Background | Swiss-Prot Acc.P36406.Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090). |
| Synonyms | ARD1; ARFD1; RNF46 |
| Reference Data | |
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