PKC beta 1 (PRKCB) Rabbit Monoclonal Antibody [Clone ID: R06-0C2]
| Product Data | |
| Clone Name | R06-0C2 |
|---|---|
| Application | IF, IHC, IP, WB |
| Recommended Dilution | WB: 1/500-1/2000 IHC: 1/50-1/200 ICC/IF: 1/50-1/200 IP: 1/50 |
| Reactivity | Human, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthesized peptide derived from human PKC beta 2 |
| Buffer | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | 77kDa |
| Gene Name | protein kinase C beta |
| Database Link | |
| Background | Swiss-Prot Acc.P05771.Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. |
| Synonyms | MGC41878; PKC-B; PKC-beta; PKCB; PRKCB1; PRKCB2 |
| Reference Data | |
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