IKB alpha (NFKBIA) Rabbit Polyclonal Antibody
| Product Data | |
| Application | IP, WB |
|---|---|
| Recommended Dilution | WB: 1/500-1/2000 IP: 1/50 |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | A synthesized peptide derived from human Phospho-IKB alpha (S32) (Phosphorylated) |
| Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration | lot specific |
| Purification | Affinity Chromatography |
| Conjugation | Unconjugated |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | 39kDa |
| Gene Name | NFKB inhibitor alpha |
| Database Link | |
| Background | Swiss-Prot Acc.P25963.Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB. IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified. |
| Synonyms | I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; MAD-3; MAD3; NFKBI |
| Reference Data | |
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