Emerin (EMD) Rabbit Monoclonal Antibody [Clone ID: R02-5J7]
| Product Data | |
| Clone Name | R02-5J7 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | WB: 1/1000 IHC: 1/20 ICC/IF: 1/50 |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthetic peptide of human Emerin |
| Buffer | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | Calculated MW: 29 kDa; Observed MW: 35 kDa |
| Gene Name | emerin |
| Database Link | |
| Background | Swiss-Prot Acc.P50402.Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. |
| Synonyms | EDMD; emerin; LEMD5; STA |
| Reference Data | |
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