Cullin 5 (CUL5) Rabbit Monoclonal Antibody [Clone ID: R02-5K8]

SKU TA384065

Cullin 5 Rabbit monoclonal Antibody

Product Data

• Clone Name: R02-5K8
• Application: WB
• Recommended Dilution: WB: 1/1000-1/5000
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant protein of human Cullin 5
• Buffer: 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
• Stability: 1 year
• Shipping: Blue Ice
• Predicted Protein Size: Calculated MW: 91 kDa; Observed MW: 91 kDa
• Gene Name: cullin 5
• Database Link:
  Q93034
• Background: Swiss-Prot Acc.Q93034.Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
• Synonyms: CUL-5; VACM-1; VACM1

Reference Data