CAF1 (CHAF1A) Rabbit Monoclonal Antibody [Clone ID: R06-3A5]
| Product Data | |
| Clone Name | R06-3A5 |
|---|---|
| Application | IF, IHC, IP, WB |
| Recommended Dilution | WB: 1/1000 IHC: 1/50 ICC/IF: 1/200-1/1000 IP: 1/20 |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthetic peptide of human p150 CAF1 |
| Buffer | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Concentration | lot specific |
| Purification | Affinity Purified |
| Conjugation | Unconjugated |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Predicted Protein Size | Calculated MW: 107 kDa; Observed MW: 150 kDa |
| Gene Name | chromatin assembly factor 1 subunit A |
| Database Link | |
| Background | Swiss-Prot Acc.Q13111.Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci . |
| Synonyms | CAF; CAF-1; CAF-Ip150; CAF1; CAF1B; CAF1P150; hp150; MGC71229; P150 |
| Reference Data | |
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