Caspase 12 (CASP12) Rabbit Polyclonal Antibody

SKU TA374279

Caspase-12 Rabbit polyclonal Antibody

Product Data

• Application: ELISA, IHC, WB
• Recommended Dilution: WB,1:500 - 1:1000; IHC-P,1:50 - 1:200; ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
• Reactivity: Human, Mouse, Rat
• Modification: Unmodified
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Buffer: Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Predicted Protein Size: 39kDa
• Gene Name: caspase 12 (gene/pseudogene)
• Database Link:
  Q6UXS9
• Background: Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene.

Reference Data