FGR Rabbit Polyclonal Antibody
| Product Data | |
| Application | IHC |
|---|---|
| Recommended Dilution | IHC: 30-150 Positive control: Human liver cancer Predicted cell location: Cytoplasm |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide of human FGR |
| Buffer | pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C. |
| Stability | 1 year |
| Shipping | Blue Ice |
| Gene Name | FGR proto-oncogene, Src family tyrosine kinase |
| Database Link | |
| Background | This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. |
| Synonyms | c-fgr; c-src2; FLJ43153; MGC75096; OTTHUMP00000003603; P55-FGR; p55c-fgr; p58c-fgr; SRC2 |
| Reference Data | |
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