RASGRP 4 (RASGRP4) Rabbit Polyclonal Antibody

SKU TA358067

RASGRP4 Antibody - N-terminal region

Product Data

• Application: WB
• Reactivity: Human
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Specificity: Expected reactivity: Human, Pig; Homology: Human: 100%; Pig: 92%
• Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Concentration: lot specific
• Purification: Affinity Purified
• Conjugation: Unconjugated
• Storage: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Stability: Shelf life: one year from despatch.
• Shipping: Blue Ice
• Predicted Protein Size: 63kDa
• Gene Name: RAS guanyl releasing protein 4
• Database Link:
  NP_001139679
  C0LTP7
• Background: The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene.
• Synonyms: RASGRP4

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: MAPK signaling pathway