Progesterone Receptor (PGR) Mouse Monoclonal Antibody [Clone ID: 16]

SKU TA355338

Progesterone Receptor Mouse Monoclonal Antibody

Product Data

• Clone Name: 16
• Application: IHC
• Recommended Dilution: 1:100
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to the N-terminal region of the A form of the human progesterone receptor
• Specificity: Human progesterone receptor. A and B forms are detected in Western blotting procedures but only the A form is detected in immunohistochemical procedures. This may be the result of the epitope being inaccessible in the folded B form of the progesterone receptor protein.
• Buffer: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Shipping: Blue Ice
• Gene Name: progesterone receptor
• Database Link:
  P06401
• Background: The human progesterone receptor (PR) is expressed as two isoforms, PRA (94 kD) and PRB (114 kD), which function as ligand-activated transcription factors. These two isoforms are transcribed from distinct estrogen receptor (ER)-inducible promoters within a single copy PR gene.; The PRA form is a truncated version of the PRB form, lacking the first 164 N-terminal amino acids. In humans, PRA acts as a transdominant repressor of the transcriptional activity of PRB, glucocorticoid receptor, ER, androgen receptor and mineralocorticoid receptor. PRB functions mainly as a transcriptional activator. PRB is expressed strongly in endometrial glandular and stromal nuclei in the proliferative phase of the menstrual cycle and weakly during the secretory phase and early pregnancy.
• Synonyms: NR3C3; PR

Reference Data