PMS2 Mouse Monoclonal Antibody [Clone ID: M0R4G]

SKU TA355318

MISMATCH (PMS2) Mouse Monoclonal Antibody

Product Data

• Clone Name: M0R4G
• Application: IHC
• Recommended Dilution: 1:100
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Prokaryotic recombinant protein corresponding to 160 amino acids of the C–terminal region of the human PMS2 molecule
• Specificity: Human PMS2
• Buffer: Liquid tissue culture supernatant containing sodium azide as a preservative
• Conjugation: Unconjugated
• Storage: Store at 2-8°C
• Stability: 12 months
• Shipping: Blue Ice
• Gene Name: PMS1 homolog 2, mismatch repair system component
• Database Link:
  P54278
• Background: Postmeiotic segregation increased 2 (PMS2), also known as PMS1 protein homologue 2, is a DNA mismatch repair (MMR) protein. The PMS2 gene family members are found in clusters on chromosome 7. PMS2 is a 96 kDa mismatch repair protein closely related to MLH1, MLH3 and PMS1, which are homologs of the bacterial mutL gene. The PMS2 protein forms a heterodimer with the MLH1 protein which is then activated in the presence of ATP; this complex coordinates the binding of other proteins that repair DNA errors arising during cell preparation for cell division.; The loss of PMS2 expression in tumors can be helpful in identifying hMLH1 mutation carriers and identifies their suitability for mutation analysis.; PMS2 gene defects account for a small but significant proportion of colorectal cancers and for a substantial proportion of tumors with microsatellite instability.
• Synonyms: HNPCC4; H_DJ0042M02.9; PMS2CL; PMSL2

Reference Data