Desmin (DES) Rabbit Polyclonal Antibody

SKU TA354683

Rabbit anti Desmin Polyclonal Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: A synthetic peptide corresponding to the C-terminus of human Desmin.
• Buffer: This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: ~55 kDa
• Gene Name: desmin
• Database Link:
  NP_001918
  P17661
• Background: Desmin is a major intermediate filament protein found exclusively in striated (skeletal or cardiac) muscle tissue. It belongs to a large family of class III intermediate filament protein, the main intermediate filamentin mature skeletal, cardiac and smooth muscle cells. Mutations in the gene encoding desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. PKC (Protein Kinase C) and cAMP-dependent protein kinase can induce disassembly of the desmin filaments by phosphorylating multiple sites at N-terminus of desmin which can affect the desmin filament structure which play a role in the regulatory process in assembly and turnover.
• Synonyms: CSM1; CSM2; LGMD2R

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)