CD45 (PTPRC) Rabbit Polyclonal Antibody

SKU TA354279

Rabbit anti CD45/LCA Polyclonal Antibody

Product Data

• Recommended Dilution: WB 0.1-1 µg/ml ELISA N/A IP N/A IHC 2-10 µg/ml FC 5-10 µg/ml
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein encoding aa 1119-1304 of human CD45.
• Buffer: This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
• Purification: The Rabbit IgG is purified by Epitope Affinity Purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 220, 205, 190, 180 kDa
• Gene Name: protein tyrosine phosphatase, receptor type C
• Database Link:
  NP_001254727
  P08575
• Background: CD45 leucocyte common antigen (LCA) belongs to the family of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. CD45 is a transmembrane tyrosine phosphatase which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. The intracellular portion of these molecules has protein phosphatase activity and is involved in regulation of transmembrane signals. CD45 plays an essential role in lymphocyte activation.
• Synonyms: B220; CD45; CD45R; GP180; L-CA; LCA; LY5; T200

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Phosphatase, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Fc gamma R-mediated phagocytosis, Primary immunodeficiency, T cell receptor signaling pathway