KPNB1 Rabbit Polyclonal Antibody

SKU TA351293

Rabbit Polyclonal Anti-KPNB1 Antibody

Product Data

• Application: IHC
• Recommended Dilution: IHC: 50-200; Positive control: Human cervical cancer; Predicted cell location: Cytoplasm or Nucleus
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human KPNB1
• Buffer: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: karyopherin subunit beta 1
• Database Link:
  NP_002256
  Q14974
• Background: Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore.
• Synonyms: IMB1; Impnb; IPO1; IPOB; NTF97

Reference Data

• Protein Families: Druggable Genome, Stem cell - Pluripotency