Artemin (ARTN) Rabbit Polyclonal Antibody

SKU TA350631

Rabbit Polyclonal Anti-ARTN Antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 500-2000; WB positive control: A431 and 231 cells
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human ARTN
• Buffer: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 23 kDa
• Gene Name: artemin
• Database Link:
  NP_476501
  Q5T4W7
• Background: The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.
• Synonyms: artemin; ENOVIN; EVN; NBN; neublastin; neurotrophic factor; neurotrophic factor artemin; OTTHUMP00000009173; OTTHUMP00000009174

Reference Data

• Protein Families: Druggable Genome, Secreted Protein