MSH4 Rabbit Polyclonal Antibody

SKU TA349403

Rabbit Polyclonal Anti-MSH4 Antibody

Product Data

• Application: IHC
• Recommended Dilution: IHC: 100-300; Positive control: Human colon cancer; Predicted cell location: Cytoplasm or Nucleus
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human MSH4
• Buffer: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: mutS homolog 4
• Database Link:
  NP_002431
  O15457
• Background: This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.
• Synonyms: mutS homolog 4; mutS homolog 4 (E. coli); OTTHUMP00000011349

Reference Data

• Protein Families: Druggable Genome