DEPDC1B Rabbit Polyclonal Antibody

SKU TA349195

Rabbit Polyclonal Anti-DEPDC1B Antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DEPDC1B antibody was raised against a 19 amino acid peptide near the carboxy terminus of human DEPDC1B
• Buffer: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: DEPDC1B antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: Predicted: 58 kDa; Observed: 57 kDa
• Gene Name: DEP domain containing 1B
• Database Link:
  NP_060839
  Q8WUY9
• Background: The DEP domain-containing 1B (DEPDC1B) protein was initially identified as a radiation response biomarker in human lymphoblastoid cell lines (1). Like the related protein DEPDC1A, expression of DEPDC1B correlates with a poor prognosis in cancer patients (2,3). Studies have shown that DEPDC1B levels are upregulated in non-small cell lung cancer (NSCLC) and have an inverse correlation with patient survival. Ectopic expression of DEPDC1B in NSCLC activated Wnt/B-catenin signaling and enhanced cell migration and invasion while silencing DEPDC1B expression suppressed these traits (2).
• Synonyms: BRCC3; XTP1

Reference Data