IZUMO1 Rabbit Polyclonal Antibody

SKU TA349189

Rabbit Polyclonal Anti-IZUMO1 Antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: IZUMO1 antibody was raised against an 18 amino acid peptide near the center of human IZUMO1
• Buffer: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: IZUMO1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: Predicted: 35, 39, 42 kDa; Observed: 52 kDa
• Gene Name: izumo sperm-egg fusion 1
• Database Link:
  NP_872381
  Q8IYV9
• Background: IZUMO1, a sperm-specific protein, is essential for sperm-egg plasma membrane binding and fusion. It is involved in the fertilization process and in the fusion of the sperm with the egg (1,2). IZUMO1 is expressed as at least four isoforms produced by alternative splicing and contains one Ig-like (immunoglobulin-like) C2-type domain (3). Lack of IZUMO1 in males, due to homozygous mutation in the gene that encodes IZUMO1, results in sterility due to an inability to penetrate the plasma membrane of the egg (4).
• Synonyms: DRLM

Reference Data