SMURF1 Rabbit Polyclonal Antibody

SKU TA349092

Rabbit Polyclonal Anti-SMURF1 Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL, IHC: 5 ug/mL
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: SMURF1 antibody was raised against a 16 amino acid peptide near the amino terminus of human SMURF1.
• Buffer: PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: SMURF1 antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: Predicted: 80, 83 kDa; Observed: 78 kDa
• Gene Name: SMAD specific E3 ubiquitin protein ligase 1
• Database Link:
  NP_065162
  Q9HCE7
• Background: SMURF1 (SMAD ubiquitin regulatory factor 1) is a negative regulator of TGF-beta signaling (1). SMURF1 and SMURF2 are members of HECT domain E3 ubiquitin ligase which are involved in the enzymatic reactions of the Ub conjugating pathway (1,2). SMURF1 negatively regulates osteoblast activity and response to bone morphogenesis protein (BMP) through controlling MEKK2 degradation (3). SMURF1 has recently been shown to play a role in breast cancer cell migration and invasion through the downregulation of RhoA (4).
• Synonyms: STAG1; TMEPAI

Reference Data