alpha smooth muscle Actin (ACTA2) Rabbit Polyclonal Antibody

SKU TA347823

Rabbit Polyclonal Anti-alpha-SMA antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 1:500-1:1000
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-alpha-SMA antibody: Synthetic peptide corresponding to N terminal residues of Human alpha smooth muscle Actin.
• Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 45 KD
• Gene Name: actin, alpha 2, smooth muscle, aorta
• Database Link:
  NP_001604
  P62736
• Background: Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.
• Synonyms: AAT6; ACTSA; MYMY5
• Note: alpha-SMA antibody detects endogenous levels of alpha-SMA.

Reference Data

• Protein Pathways: Vascular smooth muscle contraction