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TLR7 Mouse Monoclonal Antibody [Clone ID: 4G6]

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SKU
TA337157
Mouse Monoclonal TLR7 Antibody (4G6)
Size:
100 ug
Conjugation:
Unconjugated
  $660.00
5 Days*
Bulk/Customize

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Specifications
Specifications
Product Data
Clone Name 4G6
Application CyTOF-ready, FC, ICC/IF, IHC, WB
Recommended Dilution Western Blot: 10ug/ml~, Flow Cytometry: 1-2ug/10^6cells, Flow (Intracellular): 5 ug/ml, Knockout Validated, CyTOF-ready, Immunocytochemistry/ Immunofluorescence: 1:500-1:5000, Immunohistochemistry: 1:50 - 1:200, Knockdown Validated
Reactivity Human, Mouse
Antibody Host Mouse
Clonality Monoclonal
Immunogen A partial human TLR7 recombinant protein (amino acids 562-839) was used as the immunogen. 277 amino acid ( AA 562- 839)~
Buffer PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name toll like receptor 7
Database Link
Background TLR7 is a 1049 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain. It plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV). It is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8. It acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion and the inflammatory response. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
Synonyms TLR7-like
Reference Data
Protein Categories ADC Targets, Allergies and autoimmune diseases, Chemokines, Cytokines, Membrane Proteins
Protein Families Druggable Genome, Transmembrane
Protein Pathways Toll-like receptor signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.