ABCG5 Mouse Monoclonal Antibody [Clone ID: 1B5E10]

SKU TA336947

Mouse Monoclonal ABCG5 Antibody (1B5E10)

Product Data

• Clone Name: 1B5E10
• Application: ELISA, FC, IF, IHC, WB
• Recommended Dilution: Flow Cytometry: 1:200 - 1:400, ELISA: 1:10000, Immunohistochemistry: 1:200 - 1:2000, Western Blot: 1:500 - 1:2000, Immunohistochemistry-Paraffin: 1:200 - 1:2000, ICC/IF (Negative)
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Partial recombinant human ABCG5 (between residues 300-500) expressed in E. coli [UniProt Q9H222].
• Buffer: PBS, 0.03% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Ammonium sulfate precipitation
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: ATP binding cassette subfamily G member 5
• Database Link:
  NP_071881
  Q9H222
• Background: ABCG5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCG5 is a member of the White subfamily. It functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. ABCG5 is expressed in a tissue-specific manner in the liver, colon, and intestine. Mutations in this protein may contribute to sterol accumulation and atheroschlerosis, and they have been observed in patients with sitosterolemia (1).
• Synonyms: STSL

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ABC transporters