Collagen I (COL1A1) Rabbit Polyclonal Antibody

SKU TA336830

Rabbit Polyclonal Collagen I alpha 1 Antibody

Product Data

• Application: ICC/IF, IHC, WB
• Recommended Dilution: Immunocytochemistry/ Immunofluorescence: 10-20 ug/ml, Western Blot (Negative), Immunohistochemistry-Paraffin: 1:200, Immunohistochemistry: 1:200
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A synthetic peptide made to an internal portion of the human Collagen I protein (between residues 150-200) [UniProt P02452]
• Buffer: PBS, 30% glycerol, 0.1% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: collagen type I alpha 1
• Database Link:
  NP_000079
  P02452
• Background: Collagen-1 (also known as collagen alpha, COL1A1, and alpha-1 type I collagen) is the largest component of fibrillar collagen found in cartilage and connective tissues, and synthesizes by fibroblasts, osteoblasts, and odontoblasts. Trimers are formed by combing two alpha one chains and one alpha 2 chain. Mutations of the gene are found in Ehlers-Danlos syndrome, as well as osteogenesis imperfecta. Over 50 mutations have been found in these diseases, including deletions, insertions, splice variants, and substitutions.
• Synonyms: EDSC; OI1; OI2; OI3; OI4
• Note: This Collagen 1 antibody is useful for IHC-paraffin embedded sections.

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: ECM-receptor interaction, Focal adhesion