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CD31 (PECAM1) Rat Monoclonal Antibody [Clone ID: MEC13.3]

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SKU
TA336675
Rat Monoclonal CD31/PECAM-1 Antibody (MEC13.3)
Size:
100 ul
Conjugation:
Unconjugated
  $620.00
5 Days*
Bulk/Customize

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View other "CD31 or NM_000442" antibodies

Specifications
Specifications
Product Data
Clone Name MEC13.3
Application CyTOF-ready, FC, ICC/IF, IHC, IP
Recommended Dilution Immunohistochemistry-Frozen: 1:100 , Immunohistochemistry: 1:100-1:500, Immunoprecipitation: 1:10-1:500, Immunocytochemistry/ Immunofluorescence: 1:500 - 1:1000, Flow Cytometry: 2.5 ug/ml, Flow (Cell Surface): 2.5 ug/ml, In vivo assay, CyTOF-ready
Reactivity Mouse
Antibody Host Rat
Isotype IgG2a, kappa
Clonality Monoclonal
Immunogen mouse endothelial cell line T-end
Buffer PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name platelet and endothelial cell adhesion molecule 1
Database Link
Background CD31/PECAM1 is commonly used as an endothelial marker, particularly in angiogenesis. CD31 is important in assisting placental and endometrial vascular development. However, CD31 is also associated with many negative angiogenic occurrences, particularly those within or related to tumors and other disease lesions. In MS, plasma microparticules carry CD31 and are important in the formation of brain lesions associated with MS. In cardiac angiosarcoma, CD31 presence is indicative of the severity of the disease. In prostate tumor cells, CD31 is upregulated and associated with increased levels of HIF1a, VEGF, and other hypoxic markers. This relationship seems to indicate that when prostate cancer reaches a sufficient state of development that intense angiogenesis must occur in order to support the ongoing growth and survival of the cancer cells. In all, CD31 is a great marker for normal and disease-induced angiogenesis.
Synonyms CD31; EndoCAM; endoCAM; GPIIA; PECA1; PECAM-1
Note This CD31/PECAM1 Antibody (MEC13.3) is useful for Flow Cytometry, Immunoprecipitation, Immunohistochemical staining of acetone-fixed frozen sections and zinc-fixed paraffin-embedded sections, and in vitro and in vivo blocking of CD31-mediated cell-cell interactions. Please Note: NB600-1475 works well on acetone-fixed frozen sections as well as zinc-fixed paraffin-embedded sections. However, it is not recommended for formalin-fixed paraffin-embedded sections due to inconsistent results. In vivo assay was reported in scientific literature. Use in vitro assays reported in scientific literature (PMID 24647208)
Reference Data
Protein Categories ADC Targets, CD Markers, Intracellular Proteins, Membrane Proteins
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs), Leukocyte transendothelial migration
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.