Noxa (PMAIP1) Mouse Monoclonal Antibody [Clone ID: 114C307.1]

CAT#: TA336673

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Mouse Monoclonal Noxa Antibody (114C307.1)



USD 511.00


Availability*
5 Days

Size
    • 100 ug


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Specifications

Product Data
Clone Name 114C307.1
Applications IF, IHC, WB
Recommended Dilution WB: 1-2 ug/ml, IF: 1:10-1:500, IHC: 1:10-1:500, IHC-P: 5 ug/ml
Reactivities Human, Mouse
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen Noxa Antibody was developed by immunizing mice with a fusion protein containing human Noxa.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name phorbol-12-myristate-13-acetate-induced protein 1
Background Recently, a BH-3 only member of the Bcl-2 family have been identified in human and mouse and designated as Noxa (for damage) (1). The expression of the Noxa gene involves direct activation of its promoter by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Noxa cDNA codes for a 103-amino acid protein. The coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as, Bcl-XL and Mcl-1. Oda et al (1) have also shown that blocking the endogenous Noxa induction results in the suppression of apoptosis. Treatment of cells with Noxa antisense oligonucleotides blocks radiation-induced apoptosis suggesting that Noxa may represent a mediator of p53-dependent apoptosis.
Synonyms APR; NOXA
Note Immunocytochemistry and Immunofluorescence; See Yakovlev et all (2003) for details.
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways p53 signaling pathway
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