SCARB1 Rabbit Polyclonal Antibody

SKU TA336639

Rabbit Polyclonal SR-BI Antibody

Product Data

• Application: Block/Neutralize, FC, ICC/IF, IHC, Immunoblotting, IP, Simple Western, WB
• Recommended Dilution: Flow (Intracellular), Block/Neutralize, Immunohistochemistry-Frozen, Flow Cytometry: 1:400, Immunoblotting, Knockout Validated, Simple Western: 1:100, Western Blot: 1:1000-1:5000, Immunoprecipitation: 1:10-1:500, Immunocytochemistry/ Immunofluorescence: 1:50-1:1000, Immunohistochemistry: 2.5-5 ug/ml, Immunohistochemistry-Paraffin: 2.5-5 ug/ml
• Reactivity: Bovine, Hamster, Human, Mouse, Mustelid, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: A C-terminal peptide containing residues from mouse SR-BI (within residues 450-509). [UniProt# Q61009]
• Buffer: Tris-citrate/phosphate, pH 7, 0.1% Sodium azide. Store at 4C. Do not freeze.
• Concentration: lot specific
• Purification: Immunogen affinity purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 82 kDa
• Gene Name: scavenger receptor class B member 1
• Database Link:
  NP_005496
  Q8WTV0
• Background: SR-BI (scavenger receptor class B member 1, SCARB1) belongs to CD36 family and act as a receptor for several ligands including phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and HDL located in caveolae (regions over plasma membrane). It plays important role in meditating the uptake of HDL-derived cholesterol as well as cholesteryl ester in liver and steroidogenic tissues. It facilitates the flux of free and esterified cholesterol between cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. SR-BI is expressed in endothelial cells, macrophages and dendritic cells also. It has been suggested to be involved in the phagocytosis of apoptotic cells (via its phosphatidylserine binding activity); uptake of lipid soluble vitamins (vitamin E and carotenoids) and pathogen recognition, anti-inflammatory responses and its expression can be modulated by LPS as well as ROS. SR-BI has also been involved in the capture and cross-presentation of antigens from viruses, bacteria and parasites.
• Synonyms: CD36L1; CLA-1; CLA1; HDLQTL6; SR-BI; SRB1
• Note: This SR-BI antibody is useful for Flow cytometry (PMID 23029167), Western blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry paraffin embedded sections and Immunoprecipitation. In Western blot a band is observed at ~ 82 kDa in tissues that express SR-BI such as liver, ovary and adrenals and to a lesser extent testis, heart and mammary gland.Blocking/Neutralizing was reported in scientific literature. Use in Immunohistochemistry-Frozen reported in scientific literature (PMID 24244566)

Reference Data

• Protein Families: Druggable Genome, Transmembrane