Langerin (CD207) Rabbit Polyclonal Antibody

SKU TA336470

Rabbit Polyclonal Langerin/CD207 Antibody

Product Data

• Application: FC, IHC, WB
• Recommended Dilution: Western Blot: 1 - 3 ug/ml, Flow Cytometry: 1:20-1:2000, Immunohistochemistry: 1:200-1:1000, Immunohistochemistry-Frozen: 1:200-1:1000, Immunohistochemistry-Paraffin: 1:200-1:1000, Flow (Intracellular)
• Reactivity: Mouse
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Amino acids 26-44 of mouse Langerin were used as immunogen. (Genbank Accession No. CAC82936)
• Buffer: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: CD207 molecule
• Database Link:
  NP_056532
  Q9UJ71
• Background: Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Langerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.
• Synonyms: CLEC4K
• Note: A protein band of ~36 kDa is detected in mouse lung tissue lysate. Pre-incubation with the immunizing peptide completely removes langerin reactivity from NB100-56733. Confocal Microscopy: see Sun-Sang et al for details. Flow Cytometry (Intracellular): see Ness et al for details. Immunohistochemistry (frozen): see Schryver et al for details.

Reference Data

• Protein Families: Druggable Genome, Transmembrane