TEM8 (ANTXR1) Mouse Monoclonal Antibody [Clone ID: 200C1339(SB20)]

SKU TA336418

Mouse Monoclonal TEM8/ANTXR1 Antibody (200C1339(SB20))

Product Data

• Clone Name: 200C1339(SB20)
• Application: IHC, WB
• Recommended Dilution: Western Blot: 1-3 ug/ml, Immunohistochemistry: 2-5 ug/ml, Immunohistochemistry-Paraffin: 2-5 ug/ml, Immunocytochemistry/ Immunofluorescence)
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: This monoclonal antibody was developed by immunizing mice with a synthetic peptide containing amino acids 481-497 (CINFTRVKNNQPAKYPL) of human TEM8.
• Buffer: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: anthrax toxin receptor 1
• Database Link:
  NP_444262
  Q9H6X2
• Background: Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). Based on TEM8s interaction with the C5 domain of collagen a3(VI), a protein also preferentially expressed in tumor endothelium, it is thought that TEM8 plays an important role in tumor angiogenesis.
• Synonyms: ATR; GAPO; TEM8
• Note: Immunohistochemistry-Paraffin: see Hotchkiss et al 2005 for details. Immunocytochemistry/Immunofluorescence: See Matsuda (2010) for details.

Reference Data

• Protein Families: Druggable Genome, Transmembrane