TEM7 (PLXDC1) Mouse Monoclonal Antibody [Clone ID: 197C193 (IM193)]

SKU TA336403

Mouse Monoclonal TEM7/PLXDC1 Antibody (197C193 (IM193))

Product Data

• Clone Name: 197C193 (IM193)
• Application: ICC/IF, IHC, IP, WB
• Recommended Dilution: Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunohistochemistry-Frozen), Immunohistochemistry-Paraffin: 2-5 ug/ml, Immunoprecipitation: 1:10-1:500, Immunohistochemistry: 1:10-1:500, Western Blot
• Reactivity: Human, Mouse, Rat
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Amino acids 409-425 (LQNNLSPKTKGTPVHLG) of human TEM7 were used to develop this monoclonal antibody.
• Buffer: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: plexin domain containing 1
• Database Link:
  NP_065138
  Q8IUK5
• Background: Recently, using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al, have identified 46 genes, whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (EC), but were absent or barely detectable in normal ECs, and named as Tumor Endothelial Markers (TEMs, TEM 1-9). TEM7 (Tumor endothelial marker 7) transcripts are specifically expressed in the endothelium of colorectal cancer, primary cancers of lung, pancreas, breast, and brain. TEM7 is expressed specifically in endothelium of these cancers, whether primary or metastasis. The other six members of this family (TEM1, 3, 4, 5, 8, and 9) also show similar expression pattern in lung and brain tumors, and liver metastasis. Since most of the genes expressed differentially in tumor endothelium are also expressed during angiogenesis, these newly discovered genes might provide important resources for basic and clinical studies of human angiogenesis.
• Synonyms: TEM3; TEM7
• Note: Immunocytochemistry/Immunofluorescence: see Meng et al, 2007. Immunohistochemistry (frozen): see Lee et al, 2006. Immunohistochemistry (paraffin): 2-5 ug/ml; see Nanda et al, 2004 and Lee et al, 2005. Immunoprecipitation: see Nanda et al, 2004.

Reference Data

• Protein Families: Druggable Genome, Secreted Protein, Transmembrane