Caspase 8 (CASP8) Mouse Monoclonal Antibody [Clone ID: 90A992]

SKU TA336388

Mouse Monoclonal Caspase-8 Antibody (90A992)

Product Data

• Clone Name: 90A992
• Application: CyTOF-ready, FC, IHC, Simple Western, WB
• Recommended Dilution: Simple Western: 1:100, Immunohistochemistry-Paraffin: 4 ug/ml, Flow Cytometry: 0.1-0.5 ug/ml, Western Blot: 0.5-2 ug/ml, Immunohistochemistry, CyTOF-ready
• Reactivity: Human, Primate
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Amino acids PVETDSEEQP of human Caspase-8 were used as the immunogen for this antibody.
• Buffer: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: caspase 8
• Database Link:
  NP_203519
  Q14790
• Background: Caspases are a family of cysteine proteases that are key mediators of programmed cell death or apoptosis. The precursor form of all caspases is composed of a prodomain, and large and small catalytic subunits. The active forms of caspases are generated by several stimuli including ligand-receptor interactions, growth factor deprivation and inhibitors of cellular functions. All known caspases require cleavage adjacent to aspartates to liberate one large and one small subunit, which associate into a2b2 tetramer to form the active enzyme. Caspase-8 (FLICE) forms a direct link between the activation of CD95 and the caspase pathway. Overexpression of Caspase-8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family.
• Synonyms: ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Alzheimer's disease, Apoptosis, Huntington's disease, NOD-like receptor signaling pathway, p53 signaling pathway, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Viral myocarditis