TRAIL (TNFSF10) Mouse Monoclonal Antibody [Clone ID: 55B709.3]

SKU TA336381

Mouse Monoclonal TRAIL/TNFSF10 Antibody (55B709.3)

Product Data

• Clone Name: 55B709.3
• Application: IHC, WB
• Recommended Dilution: Immunohistochemistry, Western Blot: 1-2 ug/ml, Immunohistochemistry-Paraffin: 5 ug/ml
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1, kappa
• Clonality: Monoclonal
• Immunogen: This monoclonal antibody was raised against a peptide corresponding to amino acids 17-35 of human TRAIL. This peptide sequence has been shown to be involved in TRAIL and DR5 (TRAIL-R2) interaction.
• Buffer: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: tumor necrosis factor superfamily member 10
• Database Link:
  NP_003801
  P50591
• Background: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand) (6,7). TRAIL is a type II membrane protein and expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL3-6. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
• Synonyms: Apo-2L; APO2L; CD253; TL2; TRAIL

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity