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SMN1 Mouse Monoclonal Antibody [Clone ID: 2B1]

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SKU
TA336277
Mouse Monoclonal SMN Antibody (2B1)
Size:
100 ul
Conjugation:
Unconjugated
  $670.00
5 Days*
Bulk/Customize

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View other "SMN1 or NM_022874" antibodies

Specifications
Specifications
Product Data
Clone Name 2B1
Application ELISA, FC, ICC/IF, IHC, IP, WB
Recommended Dilution Immunohistochemistry, Immunocytochemistry/ Immunofluorescence: 1:250, Immunoprecipitation: 1:10-1:500, Western Blot: 2 ug/ml, Immunohistochemistry-Paraffin: 1:200, ELISA, Flow Cytometry
Reactivity Human, Mouse, Primate, Rat, Xenopus
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Purified recombinant His6-tagged human SMN protein. Swiss-Prot# Q16637
Buffer PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name survival of motor neuron 1, telomeric
Database Link
Background Spinal muscular atrophy (SMA) is a common fatal autosomal recessive disorder characterized by the degeneration of motor neurons and muscular atrophy. A gene called Survival of Motor Neurons (SMN) has been identified as the determining gene in SMA and is deleted or mutated in greater than 98% of SMA patients. The SMN protein localizes to both the cytoplasm and the nucleus. In the nucleus, SMN has been found to localize in a nuclear structure termed gems for Gemini of coiled bodies, which contain high levels of small ribonucleoproteins (snRNPs). SMN forms complexes with proteins including SIP1, Gemin 2-7 and several others known to be involved in the biogenesis of snRNPs. SMN antibodies may serve as a useful research tool to study SMN complexes and gems, and their role in pre-RNA processing and RNA metabolism.
Synonyms BCD541; GEMIN1; SMA; SMA1; SMA2; SMA3; SMA4; SMA@; SMN; SMNT; T-BCD541; TDRD16A
Note This SMN Antibody (2B1) is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin-embedded sections, Flow Cytometry, Immunoprecipitation and Western blot where a band can be seen at ~ 35 kDa. Use in ELISA reported in scientific literature (PMID 23973875)
Reference Data
Protein Categories Intracellular Proteins, Nervous system: Neurodegenerative diseases
Protein Families Druggable Genome, Stem cell - Pluripotency
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