HNMT Rabbit Polyclonal Antibody

SKU TA332537

Rabbit anti-HNMT Polyclonal Antibody

Product Data

• Application: ELISA, ICC/IF, IP, WB
• Recommended Dilution: WB,1:500 - 1:2000; IF/ICC,1:50 - 1:100; IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells; ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Buffer: Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20℃. Avoid freeze / thaw cycles.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 33kDa
• Gene Name: histamine N-methyltransferase
• Database Link:
  NP_008826
  P50135
• Background: In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
• Synonyms: HMT; HNMT-S1; HNMT-S2; MRT51

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Histidine metabolism