RRP8 Rabbit Polyclonal Antibody

CAT#: TA331959

Rabbit Polyclonal Anti-RRP8 Antibody

Product Images

Host: Rabbit; Target Name: RRP8; Sample Tissue: Fetal Kidney lysates; Antibody Dilution: 1.0ug/ml

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for Anti-RRP8 Antibody is: synthetic peptide directed towards the N-terminal region of Human RRP8. Synthetic peptide located within the following region: GKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQK
• Formulation: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
  Note that this product is shipped as lyophilized powder to China customers.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 50 kDa
• Gene Name: ribosomal RNA processing 8, methyltransferase, homolog (yeast)
• Database Link:
  NP_056139
  Entrez Gene 23378 Human
  UniProt ID O43159
• Background: RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
• Synonyms: KIAA0409; NML
• Note: Immunogen sequence homology: Human: 100%; Rat: 93%; Horse: 85%; Rabbit: 85%; Bovine: 83%