Acetylated Lysine Mouse Monoclonal Antibody [Clone ID: 15G10] Mouse Monoclonal Antibody [Clone ID: 15G10]
Product Data | |
Clone Name | 15G10 |
---|---|
Application | IF, WB |
Recommended Dilution | WB, IF |
Reactivity | Human |
Antibody Host | Mouse |
Isotype | IgG2b, kappa |
Clonality | Monoclonal |
Immunogen | Acetylated protein mixture |
Buffer | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
Concentration | lot specific |
Purification | The antibody was purified by affinity chromatography. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Shipping | Blue Ice |
Background | Proteins are reversibly and dynamically acetylated on the ε-amino group of lysine by acetyltransferases and deacetylated by deacetylases. This post-translational modification can regulate protein function (interactions with other proteins and DNA binding). Histones and transcription factors (PCAF, p53, p300, etc) appear to be the major targets of acetytransferases. Acetylation is usually associated with chromatin remodeling and transcriptional activation, although in some cases (telomeres) it is associated with gene silencing. The 15G10 antibody recognizes acetylated lysine residues on proteins. |
Reference Data |
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