Superoxide Dismutase 1 (SOD1) Rabbit Polyclonal Antibody

CAT#: TA326813

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Rabbit anti-SOD1 Polyclonal Antibody


 Product Datasheet for 'TA326813'

USD 335.00


Availability*
3 Weeks

Size
    • 100 ug


Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB 1:500 - 1:2000, IHC 1:50- 1:200
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein of human SOD1
Formulation Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration 1 mg/ml
Purification Affinity purification
Gene Name superoxide dismutase 1, soluble
Background SOD1, Cu/Zn superoxide dismutase, is a major antioxidant enzyme that catalyzes the conversion of superoxide anion to hydrogen peroxide and molecular oxygen . SOD1 is ubiquitously expressed and is localized in the cytosol, nucleus and mitochondrial intermembrane space. The SOD1 gene locus is on chromosome 21 in a region affected in Down Syndrome . In addition, over 100 distinct SOD1 inherited mutations have been identified in the familial form of amyotrophic lateral sclerosis (ALS), a progressive degenerative disease of motor neurons. Despite the fact that SOD1 helps to eliminate toxic reactive species, its mutations in ALS have been described as gain-of-function. The mechanism by which mutant SOD1 induces the neurodegeneration observed in ALS is still unclear. Mutant SOD1 proteins become misfolded and consequently oligomerize into high molecular weight species that aggregate and end up in proteinaceous inclusions.
Synonyms ALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD
Reference Data
Protein Families Druggable Genome
Protein Pathways Amyotrophic lateral sclerosis (ALS), Huntington's disease, Prion diseases
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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