KDM1B Rabbit Polyclonal Antibody

SKU TA326673

Rabbit Polyclonal KDM1B Antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: KDM1B antibody was raised against a 17 amino acid peptide near the amino terminus of human KDM1B.
• Buffer: KDM1B antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: KDM1B antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: Predicted: 65 kDa; Observed: 68 kDa
• Gene Name: lysine demethylase 1B
• Database Link:
  NP_694587
  Q8NB78
• Background: Flavin-dependent histone demethylases regulate histone lysine methylation, an epigenetic mark that regulates gene expression and chromatin function (reviewed in 1). KDM1B is a recently identified histone H3K4 demethylase that is required to establish maternal genomic imprints; targeted disruption of the KDM1B gene in mice led to lethality in their embryos, suggesting demethylation of H3K4 is critical for establishing the DNA methylation imprints (2). KDM1B has also been shown to play a role in the transcription elongation in several genes (3).
• Synonyms: AOF1; bA204B7.3; C6orf193; dJ298J15.2; LSD2

Reference Data

• Protein Families: Druggable Genome