DOPA Decarboxylase (DDC) Rabbit Polyclonal Antibody

SKU TA326643

Rabbit Polyclonal DDC Antibody

Product Data

• Application: IF, IHC, WB
• Recommended Dilution: WB: 1 - 2 ug/mL
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: DDC antibody was raised against a 14 amino acid peptide near the carboxy terminus of human DDC
• Buffer: DDC Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: DDC Antibody is affinity chromatography purified via peptide column.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: Predicted: 53 kDa; Observed: 50 kDa
• Gene Name: dopa decarboxylase
• Database Link:
  NP_000781
  P20711
• Background: DOPA decarboxylase (DDC) belongs to the group II decarboxylase family of proteins (1). It is an important protein in the catecholamine biosynthesis pathway. DDC catalyzes the second reaction in the biosynthesis of catecholamines, trace amines and serotonin (1,2). It can form a homodimer and is expressed in the central nervous system (2). DDC can be used as markers for dopaminergic, noradrenergic and serotonergic neurons in a variety of applications including depression, schizophrenia, Parkinson's disease, neuroendocrine tumors and drug abuse (3,4). Defects in DDC gene may cause the autosomal recessive disorder AADC deficiency (4).
• Synonyms: AADC

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Histidine metabolism, Metabolic pathways, Phenylalanine metabolism, Tryptophan metabolism, Tyrosine metabolism