Amyloid Precursor Protein (APP) Rabbit Polyclonal Antibody

SKU TA326459

Rabbit Polyclonal Anti-Amyloid Oligomers (A11) Antibody

Product Data

• Application: WB
• Recommended Dilution: IHC: 1:1000-1:10000, IP: 1:1000
• Reactivity: Eukaryote, Human, Mouse, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Synthetic molecular mimic of soluble oligomers.
• Buffer: PBS, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein A Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: amyloid beta precursor protein
• Database Link:
  NP_000475
  P05067
• Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils.Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres . These include the amyloid- peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimers symptomology, the deposition of -synuclein in the Lewy bodies of Parkinsons disease, and accumulation of polyglutamine-containing aggregates in Huntingtons disease .
• Synonyms: AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
• Note: Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Alzheimer's disease