PTP kappa (PTPRK) Rabbit Polyclonal Antibody

SKU TA323866

Anti-PTPRK Rabbit Polyclonal Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: ELISA: 1:2000-5000, WB: 1:500-2000, IHC: 1:25-100
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 25 kDa
• Gene Name: protein tyrosine phosphatase, receptor type K
• Database Link:
  NP_001129120
  Q15262
• Background: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. This PTP possesses an extracellular region; a single transmembrane region; and two tandem catalytic domains; and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain; an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction; possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1; which may be important for the inhibition of keratinocyte proliferation.
• Synonyms: R-PTP-kappa

Reference Data

• Protein Families: Druggable Genome, Phosphatase, Transmembrane