Cathepsin E (CTSE) Rabbit Polyclonal Antibody

SKU TA323085

Anti-CTSE Rabbit Polyclonal Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 500-2000; WB positive control: Human stomach cancer and mouse stomach tissue; IHC: 50-200; Positive control: Human gasrtic cancer; Predicted cell location: Cytoplasm
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to a region derived from 57-367 amino acids of Human Cathepsin E
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: cathepsin E
• Database Link:
  NP_001901
  P14091
• Background: The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease; which is a member of the peptidase C1 family; has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears; therefore; to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene.
• Synonyms: CATE

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Lysosome