BAG3 Rabbit Polyclonal Antibody

SKU TA322772

Anti-BAG3 rabbit polyclonal antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: ELISA: 1:1000-2000, WB: 1:500-2000,IHC: 1:15-50
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to C terminal 200 amino acids of human BCL2-associated athanogene 3
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 62 kDa
• Gene Name: BCL2 associated athanogene 3
• Database Link:
  NP_004272
  O95817
• Background: BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
• Synonyms: BAG-3; BIS; CAIR-1; MFM6

Reference Data

• Protein Families: Druggable Genome