GDNF Receptor alpha 1 (GFRA1) Rabbit Polyclonal Antibody

SKU TA322638

Anti-GFRA1 Rabbit Polyclonal Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 500-2000; WB positive control: Rat brain tissue lysate; IHC: 50-200; Positive control: Human brain; Predicted cell location: Cytoplasm
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 370-384 amino acids of Human GDNF family receptor alpha 1
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 51 kDa
• Gene Name: GDNF family receptor alpha 1
• Database Link:
  NP_005255
  P56159
• Background: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related; potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN; and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.
• Synonyms: GDNFR; GDNFRA; GFR-ALPHA-1; RET1L; RETL1; TRNR1

Reference Data

• Protein Families: Druggable Genome