ACK1 (TNK2) Rabbit Polyclonal Antibody

SKU TA322554

Anti-TNK2 Rabbit Polyclonal Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 1000-5000; WB positive control: 231 cells; IHC: 50-200; Positive control: Human breast cancer; Predicted cell location: Cytoplasm
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide peptide corresponding to a region derived from 870-884 amino acids of human tyrosine kinase, non-receptor, 2
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 119 kDa
• Gene Name: tyrosine kinase non receptor 2
• Database Link:
  NP_005772
  Q07912
• Background: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene; but the full-length nature of only two transcript variants has been determined.
• Synonyms: ACK; ACK-1; ACK1; p21cdc42Hs

Reference Data

• Protein Families: Druggable Genome, Protein Kinase